ZITHROMAX 500 MG 3 CAPSULES
Zithromax (Azithromycin) is an antibiotic that fights bacteria.
Azithromycin is used to treat many different types of infections caused by bacteria, such as respiratory infections, skin infections, ear infections, eye infections, and sexually transmitted diseases.
Azithromycin may also be used for purposes not listed in this medication guide.
ACTIVE INGREDIENT OF ZITHROMAX 500 mg
Mechanism of action
Azithromycin is an azalide, and a member of a subclass of macrolide antibiotics with bacteriocidal and bacteriostatic activities. Azithromycin reversibly binds to the 50S ribosomal subunit of the 70S ribosome of sensitive microorganisms, thereby inhibiting the translocation step of protein synthesis, wherein a newly synthesized peptidyl tRNA molecule moves from the acceptor site on the ribosome to the peptidyl (donor) site, and consequently inhibiting RNA-dependent protein synthesis leading to cell growth inhibition and cell death.
What are the Side Effects of Azithromycin ?
- Stomach upset, diarrhea /loose stools, nausea, vomiting, or abdominal pain may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
- Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
- Hearing changes (such as decreased hearing, deafness)
- Eye problems (such as drooping eyelids, blurred vision), difficulty speaking/swallowing, muscle weakness
- Signs of liver problems (such as unusual tiredness, persistent nausea/vomiting, severe stomach/abdominal pain, yellowing eyes/skin, dark urine).
- Get medical help right away if any of these rare but serious side effects occur: fast/irregular heartbeat, severe dizziness, fainting.
- This medication may rarely cause a severe intestinal condition (Clostridium difficile-associated diarrhea) due to resistant bacteria.
- This condition may occur during treatment or weeks to months after treatment have stopped.
What is azithromycin used to treat?
Azithromycin is used to treat a wide variety of bacterial infections.
It is a macrolide-type antibiotic. It works by stopping the growth of bacteria.
This medication will not work for viral infections
Unnecessary use or misuse of any antibiotic can lead to its decreased effectiveness.
Azithromycin is used to treat certain bacterial infections, such as bronchitis; pneumonia; sexually transmitted diseases (STD); and infections of the ears, lungs, sinuses, skin, throat, and reproductive organs.
Azithromycin also is used to treat or prevent disseminated Mycobacterium avium complex (MAC) infection.
Azithromycin is in a class of medications called macrolide antibiotics. It works by stopping the growth of bacteria.
Using antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment.
What is the dose of Zithromax?
Immediate-release: 500 mg orally as a single dose on day 1, followed by 250 mg orally once a day on days 2 to 5
Extended-release: 2 g orally once as a single dose
Extended-release formulations should be taken on an empty stomach.
- 30 mg/kg PO x 1 dose OR
- Alternative dosing
- 10 mg/kg PO qDay for 3 days OR
- 10 mg/kg PO x 1 dose on Day 1 followed by 5 mg/kg on Days 2-5
≥6 months: 10 mg/kg PO x 1 dose on Day 1, followed by 5 mg/kg PO on Days 2-5
≥2 years: 12 mg/kg PO qDay for 5 days; not to exceed 500 mg/day
Precautions when taking Zithromax
Do not take antacids that contain aluminum or magnesium within 2 hours before or after you take azithromycin, such as Maalox, Gaviscon and other antacids. These antacids can make azithromycin less effective when taken at the same time.
Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.
Avoid exposure to sunlight or tanning beds. Azithromycin can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.
Avoid other drugs that can cause QT prolongation or irregular heart rhythm.
Azithromycin and COVID-19 treatment
The COVID-19 infection due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a major public health issue worldwide. Many clinical studies are ongoing. SARS coronavirus infections are known to induce inflammation and subsequent tissue damage in the lungs in moderate-to-severe cases. We believe the antibacterial macrolide azithromycin has a special and interesting profile in this search for drug therapy for COVID-19.
It has been shown that azithromycin has significant antiviral properties. It has antiviral activity and it has been shown in vitro and/or in vivo on a large panel of viruses such as Ebola, Zika, respiratory syncytial virus, influenzae H1N1 virus, enterovirus, and rhinovirus.