VETOCETAMOL 24 TAB; paracetamol, caffeine, analgesics .
ACTIVE-INGREDIENT OF VETOCETAMOL 24 TAB
Each tablet contains: Paracetamol 500 mg and Caffeine anhydrous 65 mg.
INDICATION OF VETOCETAMOL 24 TAB
Vetocetamol is a mild analgesic and antipyretic formulated to give extra pain relief. The tablets are recommended for the treatment of most painful and febrile conditions, for example, headache, including migraine, backache, toothache, rheumatic pain and dysmenorrhea, and the relief of the symptoms of colds, influenza and sore throat.
DOSAGE OF VETOCETAMOL 24 TAB
Follow all directions given to you by your pharmacist or doctor carefully . They may differ from the information contained in this leaflet
Ask your pharmacist or doctor for help if you do not understand the instructions on the box .
The recommended dose is : –
Adults: Two tablets up to four times daily. The dose should not be repeated more frequently than every 4 hours. Do not exceed 8 tablets in 24 hours. Elderly: As for adults. Children: Not recommended for children under 12 years. For oral administration only.
OVER-DOSAGE OF VETOCETAMOL 24 TAB
Liver damage is possible in adults who have taken 10 g or more of paracetamol. Ingestion of 5 g or more of paracetamol may lead to liver damage if the patient has risk factors. Risk factors: If the patient; a- Is on the long term treatment with carbamazepine, phenobarbitone, phentoin, primidone, rifampicin, St John’s Wort or other drugs that induce liver enzymes. Or b- Regularly consumes ethonl in excess of recommended amounts. Or c- Is likely to be glutathione deplete e.g. eating disorders , cystic fibrosis, HIV infection, starvation and cachexia. Symptoms: Symptoms of paracetamol overdosage in the first 24 hours are pallor, nausea, vomiting, anorexia and abdominal pain. Liver damage may become apparent 12 to 48 hours after ingestion. Abnormalities of glucose metabolism and metabolic acidosis may progress to encephalopathy, hemorrhage, hypoglycemia, cerebral edema, and death. Acute renal failure with acute tubular necrosis, strongly suggested by loin pain, hematuria and proteinuria, may develop even in the absence of severe liver damage. Cardiac arrhythymias and pancreatitis have been reported. Management: Immediate treatment is essential in the management of paracetamol overdose. Despite a lack of significant early symptoms, patients should be referred to hospital urgently for immediate medical attention. Symptoms may be limited to nausea or vomiting and may not reflect the severity of overdose or the risk of organ damage. Management should be in accordance with established treatment guidlines. Treatment with activated charcoal should be considered if the overdose has been taken within 1 hour. Plasma paracetamol concentration should be measured at 4 hours or later after ingestion (earlier concentrations are unreliable). Treatment with N-acetylcysteine may be used up to 24 hours after ingestion of paracetamol; however, the maximum protective effect is obtained up to 8 hours post-ingestion. The effectiveness of the antidote declines sharply after this time. If required, the patient should be given intravenous N-acetylcysteine, in line with the established dosage schedule. If vomiting is not a problem, oral methionine may be a suitable alternative for remote areas, outside hospital. Management of patients who present with serious hepatic dysfunction beyond 24h from ingestion should be discussed with a liver unit. Caffeine: Symptoms: Overdose of caffeine may result in epigastric pain, vomiting, diuresis, tachycardia or chardiac arrhythmia and CNS stimulation (insomnia, restlessness, excitement, agitation,anxiety, tremors and convulsions). It must be noted that for clinically significant symptoms of caffeine overdose to occur with this product, the amount ingested would be associated with serious paracetamol-related liver toxicity. Management: Patients should receive general supportive care (e.g. hydration and maintenance of vital signs). The administration of activated charcoal may be beneficial when performed within one hour of the overdose, but can be considered for up to four hours after the overdose. The cns effects of overdose may be treated with intravenous sedatives. Summary: Treatment of overdose with Vetocetamol Tablets requires assessment of plasma paracetamol levels for antidote treatment, with signs and symptoms of caffeine toxicity being managed symptomatically.
CONTRA-INDICATION OF VETOCETAMOL 24 TAB
Hypersensitivity to paracetamol, caffeine or any of the other ingredients.
STORAGE OF VETOCETAMOL 24 TAB
Store at temperature not exceeding 30 °C, in a dry place.
PACK OF VETOCETAMOL 24 TAB
Carton box containing 2 (Al/opaque PVC) strips each of 12 tablets and inner leaflet.
VETOCETAMOL 24 TAB MANUFACTURED BY
The Arab Company for Gelatin and Pharmaceuticals Products For : Vetopharm Nerhadou International for Pharmaceuticals & chemicals Borg El Arab-Alexandria.