URSO PLUS 20 CAP; ursodiol, silymarin, gastrointestinal agents .
ACTIVE-INGREDIENT OF URSO PLUS 20 CAP
one ursoplus capsule contains the following active ingredients : ursodeoxycholic acid 250 mg . Silymarin (70% ) 140 mg .
INDICATION OF URSO PLUS 20 CAP
for the symptomatic treatment of primary billiary cirrhosis (PBC) , provided there is no decompensated hepatic cirrhosis > as a liver support to improve liver functions . For the dissolution of radiolucent cholesterol gallstones not larger than 15 mm in diameter in patients with a still functioning gall bladder despite the gall stone (s) .
DOSAGE OF URSO PLUS 20 CAP
Follow all directions given to you by your pharmacist or doctor carefully . They may differ from the information contained in this leaflet
Ask your pharmacist or doctor for help if you do not understand the instructions on the box .
The recommended dose is : –
the dose differs according to the type of illness and the response of the patient . The following daily dose is recommended for the symptomatic treatment of cholestatic liver disease e.g . Primary biliary cirrhosis (PBC) : + the daily dose of ursodeoxycholic acid is 13-15 mg/kg/day for adults with cholestatic diseases > = the following regimen is recommended : – 34 to 50 kg : 2 capsules : 1 morning + 1 evening > – 51 to 70 kg : 3 capsules : 1 morning + 2 evening . 71 to 100 kg : 4 capsules : 1 morning + 3 evening > over 100 kg : 5 capsules : 1 morning + 1 midday = 3 evening . = and the above daily dose of ursodeoxycholic acid is compatible with that of silymarin , which depends on the patient’s condition , ranging from 2 to 3 capsules (approx . 140-400 mg ) . the capsules should be swallowed whole with some liquid . care should be taken to ensure that they are taken regularly . +the use of ursoplus capsules in primary biliary cirrhosis may be continued indefinitely . = in patients with primary bililary cirrhosis , in rare cases the clinical symptoms may worsen at the begining of treatment , e.g . pruritus may increase . should thus occur , therapy should be continued with a dose of one ursoplus capsule daily , and the dosage then gradually increased ( by 1 capsule daily each week ) until the dose indicated in the respective dosage regimen is reached .
OVER-DOSAGE OF URSO PLUS 20 CAP
diarrhea may occur in cases of overdose . In general , other symptoms of overdose are unlikely because the absorption of ursodeoxycholic acid decreases with increasing dose and therefore more is excreted with the feces . If diarrhea occurs , the dose must be reduced and in cases of persistent diarrhea , the therapy should be discontinued . no specific counter – measures are necessary and the consequences of diarrhea should be treated symptomatically with restoration of fluid and electrolyte balance .
CONTRA-INDICATION OF URSO PLUS 20 CAP
ursoplus capsule may not be used in : acute inflammation of the gall bladder or biliary tract . Occlusion of the biliary tract ( occlusion of the common bile duct or cystic duct ) . – ursoplus capsules should not be used in : patients with a gall bladder that cannot be visualized radiologically . calcified gallstones . impaired contractillity of the gall bladder . frequent biliary colic .
STORAGE OF URSO PLUS 20 CAP
no special storage precautions necessary .
PACK OF URSO PLUS 20 CAP
a box of 2 strips , each strip contains 10 capsules .
URSO PLUS 20 CAP MANUFACTURED BY