UNASYN 375 MG 12 TAB

Each tablet contains 506.3 mg sultamicillin tosylate dihydrate equivalent to 375 mg sultamicillin.

60.00 EGP

Out of stock

UNASYN 375 MG 12 TAB

UNASYN (Ampicillin) is a broad-spectrum, semi-synthetic, beta-lactam penicillin antibiotic with bactericidal activity. Ampicillin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall and causes cell lysis. Ampicillin is stable against hydrolysis by a variety of beta-lactamases, therefore, can be used in wide range of gram-positive and -negative infections.

 

Active Ingredient Of UNASYN

Ampicillin, Sulbactam

 

Mechanism of action

UNASYN is a drug combination of beta-lactamase inhibitor used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. To begin with, the name “penicillin” can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. UNASYN has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of Ampicillin results from the inhibition of cell wall synthesis and is mediated through Ampicillin binding to penicillin binding proteins (PBPs). Ampicillin is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases.

 

What is the dosage of UNASYN according to each case ?

Dosage Forms & Strengths

powder for solution

  • 5g (ampicillin 1g/sulbactam 0.5g)
  • 3g (ampicillin 2g/sulbactam 1g)
  • 15g (ampicillin 10g/sulbactam 5g)

Gynecologic Infections

1.5 g (1 g ampicillin + 0.5 g sulbactam) to 3 g (2 g ampicillin + 1 g sulbactam) IV/IM q6hr; not to exceed 12 g/day

Intra-Abdominal Infections

1.5 g (1 g ampicillin + 0.5 g sulbactam) to 3 g (2 g ampicillin + 1 g sulbactam) IV/IM q6hr; not to exceed 12 g/day

Skin & Skin Structure Infections

1.5 g (1 g ampicillin + 0.5 g sulbactam) to 3 g (2 g ampicillin + 1 g sulbactam) IV/IM q6hr; not to exceed 12 g/day

Orbital Cellulitis

3 g (2 g ampicillin + 1 g sulbactam) IV q6hr

Pelvic Inflammatory Disease

3 g (2 g ampicillin + 1 g sulbactam) IV q6hr

Pneumonia

Aspiration or community acquired: 1.5 g (1 g ampicillin + 0.5 g sulbactam) to 3 g (2 g ampicillin + 1 g sulbactam) IV q6hr for 5 or more days

Hospital acquired: 3 g IV q6hr for 5 or more days

Urinary Tract Infections

Pyelonephritis: 3 g (2 g ampicillin + 1 g sulbactam) IV q6hr for 14 days

Acute Bacterial Rhinosinusitis (Off-label)

Severe infection requiring hospitalization

1.5 g (1 g ampicillin + 0.5 g sulbactam) to 3 g (2 g ampicillin + 1 g sulbactam) IV q6hr for 5-7 days

Endocarditis (Off-label)

Enterococcus infection resistant to penicillin/susceptible to aminoglycosides: 3 g (2 g ampicillin + 1 g sulbactam) IV q6hr for 6 weeks if not aminoglycoside resistant; >6 weeks if aminoglycoside resistant

HACEK infection: 3 g (2 g ampicillin + 1 g sulbactam) IV q6hr for 4 weeks

Therapeutic Uses

  • Endocarditis Prophylaxis
  • Endocarditis
  • Genitourinary Tract Infections (excluding Gonorrhea)
  • Gonorrhea
  • Gastrointestinal Tract Infections
  • Respiratory Tract Infections
  • Bacterial Meningitis

 

What are the side effects of Ampicillin ?

  • acute inflammatory skin eruption
  • redness and peeling of the skin (exfoliative dermatitis)
  • rash
  • inflammation of the tongue
  • Nausea
  • Yeast infection
  • swelling or inflammation of the large intestines
  • inflammation of the mouth
  • vomiting
  • low white blood cells
  • Anemia

 

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