suprax is an orally active cephalosporin antibiotic which has marked in vitro bactericidal activity against a wide variety of gram – positive and gram-negative organisms . It is indicated for the treatment of the following acute infections : when caused by susceptible micro-organisms : – upper respiratory tract infections (URTI) : eg . otitis media ; and other URTI where the causative organism is known or suspected to be resistant to other commonly used antibiotics , or where treatment failure may carry significant risk . – lower respiratory tract infection : e.g. bronchitis . – urinary tract infections : e.g. cystitis , cystourethritis , uncomplicated pylenophritis . clinical efficacy has been demonstrated in infections caused by commonly occuring pathogens including streptococcus pneumoniae , streptococcus pyogens , escherichia coli , proteus mirabilis , kliebsiella species . haemophilus influenzae ( beta-lactamse positive and negative ) , branhamella catarrhalis ( beta-lactamase positive and negative ) and enterobacter species . suprax is highly stable in the presence of beta-lactamase enzymes . most strains of enterococci ( streptococcus laecalis , group D streptococci ) and streptococci ( including coagulase positive and negative strains and meticillin-resistant strains ) are resistant to suprax . in addition , most strains of pseudomonas , bacleriodes fragalis , listeria monocytogenes and clostridia are resistant to suprax .

DOSAGE OF SUPRAX 200 MG CAP

Follow all directions given to you by your pharmacist or doctor carefully . They may differ from the information contained in this leaflet

Ask your pharmacist or doctor for help if you do not understand the instructions on the box .

The recommended dose is : –

absorbtion of suprax is not significantly modified by the presence of food . The usual course of treatment is 7 days . This may be continued for up to 14 days if required . -adults and children over 10 years : the recommended adult dosage is 200-400 mg daily according to the severity of infection , given either as a single dose or in two divided doses . – the elderly : elderly patients may be given the same dose as recommended for adults . renal function should be assessed and dosage should be adjusted in severe renal impairment . dosage in renal impairment : suprax may be administered in the presence of impaired renal function . normal dose and schedule may be given in patients with creatinine clearances of 20 ml/min or greter . in patients whose creactinine clearances is less than 20 ml/min , it is recommended that a dose of 200 mg once daily should not be exceeded . the dose and regimen for patients who are maintained on chronic amulatory peritoneal dialysis or haemodialysis should follow the same recommendation as that for patients with creatinine clearances of less than 20 mg/min .

OVER-DOSAGE OF SUPRAX 200 MG CAP

thereis no experience with overdoses with suprax . Adverse reactions seen at dose levels up to 2 g suprax in normal subjectes did not differ from the profile seen in patients treated at the recommended doses . No specific antidote exists . Cefixime is not removed from the circulation in significant quantities by dialysis . general supportive measures are recommended .

CONTRA-INDICATION OF SUPRAX 200 MG CAP

patients with known hypersensitivity to cefixime , to othercephalosporins or to any of the e4xcipients . Previous immediate and or sever hypersensitivity reaction to a penicillin or to any other beta-lactam medicinal products .

STORAGE OF SUPRAX 200 MG CAP

store at temperature not exceeding 30° C in dry place . Keep away from reach of children .
PACK OF SUPRAX 200 MG CAP
carton box containing one PVC/AL blisters , of 8 hard gelatin capsules with leaflet .
SUPRAX 200 MG CAP MANUFACTURED BY
The Egyptian Co. for Pharmaceutical & Chemical Industries (EPCI)

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