Action SPIROMAX F SOLUTION 50ML :

For Androgenetic alopecia and alopecia areata.

 

Application SPIROMAX F SOLUTION 50ML :

4 puffs twice daily.

 

What is topical Spironolactone

 

Spironolactone acts as an androgen antagonist by competitively blocking androgen receptors, as well as inhibiting ovarian androgen production (15,16).

One particular study conducted in 1988 saw six healthy male patients use a topical spironolactone to a well-defined skin area.

It concluded that the product worked to a local effect without much systemic absorption (17).

However, as this was such a small sample size, I think that it is fair to say that much more research is needed.

I have found that the most common strength used is between 1-3%.

 

What is Topical Finasteride

 

Finasteride works by inhibiting 5AR II enzyme, which is responsible for catalysing the conversion of testosterone to the much more active chemical DHT (14).

A study of 24 healthy males conducted in 2014 evaluated a newly developed finasteride 0.25% topical solution, in comparison to the marketed finasteride 1mg tablet, looking at the movement of drugs within the body and suppressive effects on plasma DHT.

It concluded that a strong and similar inhibition of plasma DHT was found after one week of treatment with both the topical and tablet, albeit finasteride plasma exposure was significantly lower with the topical than with the oral product (18).

 

Understanding the hair cycle

 

• Hair growth occurs in a series of stages, starting with the anagen phase.
• During this period, cell division in the matrix of the hair bulb, which forms the base of the hair follicle, produces keratinocytes and these form the various layers of the individual hair shaft.
• Melanocytes in the hair bulb provide the keratinocyte with pigment. After the hair reaches a certain length, which varies depending on the body region, it enters the catagen phase, when cell division and pigmentation cease (2).
• During the telogen phase, a new follicle appears below the original follicle, the hair shaft grows back into the original follicle, and the previous hair shaft is shed. It is the dysfunctions during the telogen and anagen stages that appear to result in hair loss.

 

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