ONE ALPHA 1MCG CAP; vitamin d2, alfa calcidol, metabolic bone disease agents|therapeutic nutrients, minerals, electrolytes .
ONE ALPHA 1MCG CAP
ACTIVE-INGREDIENT OF ONE ALPHA 1MCG
ALFACALCIDOL 1 µg .
INDICATION OF ONE ALPHA 1MCG
diseases caused by disturbances in the calcium metabolism in consequence of reduced endogenous production of 1,25- dihydroxyvitamin D3 . Renal osteodystrophy , postoperative or idiopathic hypoparathyrodisim , pseudohypoparathyrodism , as an adjunct to the management of terriary hyperparathyrodism , vitamin D-resistant rickets or osteomalacia , vitamin D-dependent rickets , malabsorption of calcium , osteoporosis , malabsorptive and nutritional rickets , and osteomalacia .
DOSAGE OF ONE ALPHA 1MCG
Follow all directions given to you by your pharmacist or doctor carefully . They may differ from the information contained in this leaflet
Ask your pharmacist or doctor for help if you do not understand the instructions on the box .
The recommended dose is : –
initial dose : adults and children above 20 kg body weight : 1 µg daily . Children under 20 kg body weight : 0.05 µg/kg/day . It is important to adjust the dosage according to the biochemical responses to avoid hypercalcaemia . Indices of response include levels of serum calcium . alkaline phosphatase , parathyroid hormone , urinary calcium excretion as well as radiographic and histological investigations . patients with marked bone disease ( other than those with renal failure ) may tolerate higher doses without developing hypercalcemia . however , failure of the serum calcium to rise promptly in osteomalacic patients does not necessary mean that a higher dose is required , since calcium from increased intestinal calcium absorption may be incorported into demineralized none . most patients will respond to doses between 1 and 3 µg daily . the dose requirements generally decrease in patients with bone disease when there is biochemical or radiographic evidence of bone healing and in hypoparathyroid patients after normal serum calcium levels have been obtained . maintenance doses are generally in the range of 0.25 – 2 µg daily . patients currently taking barbiturates or other anticonvulsants may need larger doses of one-alpha to produce the desired effect .
OVER-DOSAGE OF ONE ALPHA 1MCG
hypercalcemia is treated by stopping treatment with one-alpha . Severe hypercalcemia may require additional treatment with a ‘loop’ diuretic , intravenous fluids and corticosteroids .
CONTRA-INDICATION OF ONE ALPHA 1MCG CAP
STORAGE OF ONE ALPHA 1MCG CAP
store at controlled room temperature 15-25 C . Protect from direct sunlight .
PACK OF ONE ALPHA 1MCG CAP
30 capsules .
ONE ALPHA 1MCG CAP MANUFACTURED BY
paced by minapharm under licence of LEO PHARMACEUTICAL PRODUCTS .