NEXIUM 40MG 14 TAB; esomeprazole, gastrointestinal agents .
ACTIVE-INGREDIENT OF NEXIUM 40MG 14 TAB
Each tablet contains: Esomeprazole 40 mg.
INDICATION OF NEXIUM 40MG 14 TAB
Nexium tablets are indicated for : Adults and adolescents from the age of 12 years: Gastroesophageal Reflux Disease (GERD): – treatment of erosive reflux esophagitis. – long-term management of patients with healed esophagitis to prevent relapse. – symptomatic treatment of gastroesophageal reflux disease (GERD). Adults: In combination with appropriate antibacterial therapeutic regimens for the eradication of Helicobacter pylori and – healing of Helicobacter pylori associated duodenal ulcer and – prevention of relapse of peptic ulcers in patients with Helicobacter pylori associated ulcers. Patients requiring continued NSAID therapy: – healing of gastric ulcers associated with NSAID therapy. – prevention of gastric and duodenal ulcers associated with NSAID therapy, in patients at risk . Prolonged treatment after i.v. induced prevention of rebleeding of peptic ulcers. Treatment of Zollinger Ellison Syndrome.
DOSAGE OF NEXIUM 40MG 14 TAB
Follow all directions given to you by your pharmacist or doctor carefully . They may differ from the information contained in this leaflet
Ask your pharmacist or doctor for help if you do not understand the instructions on the box .
The recommended dose is : –
The tablets should be swallowed whole with liquid . The tablets should not be chewed or crushed. For patients who have difficulty in swallowing the tablets can also be dispersed in half a glass of non-carbonated water. No other liquids should be used as the entering coating may be dissolved. Stir until the tablets disintegrate and drink the liquid with the pellets immediately or within 30 minutes. Rinse the glass with half a glass of water and drink. The pellets must not be chewed or crushed. For patients who cannot swallow, the tablets can be dispersed in non-carbonated water and administered through a gastric tube. It is important that the appropriateness of the selected syringe and tube is carefully tested. Adults and adolescents from the age of 12 years. Gastro esophageal reflux Disease (GERD): Treatment of erosive reflux esophagitis: 40 mg once daily for 4 weeks. An additional 4 weeks treatment is recommended for patients in whom esophagitis has not healed or who have persistent symptoms. Long-term management of patients with healed esophagitis to prevent relapse 20 mg once daily. Symptomatic Treatment of Gastroesophageal Reflux Disease (GERD): 20 mg once daily in patients without esophagitis, if symptoms control has not been achieved after 4 weeks, the patient should be further investigated. Once symptoms have resolved, subsequent symptom control can be achieved using 20 mg once daily, when needed can be used in NSAID treated patients at risk of developing gastric and duodenal ulcers, subsequent symptom control using and on demand regimen not recommended. Adults : In combination with an appropriate antibacterial therapeutic regimen for eradication of Helicobacter pylori and – Healing of Helicobacter pylori associated duodenal ulcer and – Prevention of relapse of peptic ulcers in patients with Helicobacter pylori associated ulcers 20 mg NEXIUM with 1 g amoxicillin and 500 mg clarithromycin all twice daily for 7 days. Patients requiring continued NSAID therapy: – Healing of gastric ulcers associated with NSAID therapy the usual dose is 20 mg once daily the treatment duration is 4-8 weeks. Prevention of gastric and duodenal ulcers associated with NSAID therapy in patients at risk: 20 mg once daily. Treatment of Zoilinger-Ellison syndrome: The recommended initial dosage is NEXIUM 40 mg twice daily the dosage should be individually adjusted and treatment continued as long as clinically indicated. Based on the clinical data available the majority of patients can be controlled on doses between 80 to 160 mg esomeprazole daily with doses above 80 mg daily the dose should be divided and given twice daily. Children below the age of 12 years: NEXIUM tablets should not be used in children younger than 12 years since no data is available. Impaired renal function: Dose adjustment is not required in patients with impaired renal function due to limited experience in patients with severe renal insuffciency; such patients should be treated with caution. Impaired hepatic function: Dose adjustment is not required in patients with mild to moderate liver impairment . For patients with severe liver impairment . A maximum dose of 20 mg NEXIUM should not be exceeded. Elderly: Dose adjustment is not required in the elderly.
OVER-DOSAGE OF NEXIUM 40MG 14 TAB
There is very limited experience to date with deliberate overdose. The symptoms described in connection with 280 mg were gastrointestinal symptoms and weakness. Single doses of 80 mg esomeprazole were uneventful. No specific antidote is known. Esomeprazole is extensively plasma protein bound and is therefore not readily dialyzable. As in any case of overdose, treatment should be symptomatic and general supportive measures should be utilised.
CONTRA-INDICATION OF NEXIUM 40MG 14 TAB
Known hypersensitivity to esomeprazole, subsituted benzimidazoles or any other constituents of the formulation. Esomeprazole should not be used concomitantly with nelfinavir.
STORAGE OF NEXIUM 40MG 14 TAB
Do not store above 30 °C. Store in the original package (blister) in order to protect from moisture.
PACK OF NEXIUM 40MG 14 TAB
Carton box contains 14 tablets.
NEXIUM 40MG 14 TAB MANUFACTURED BY
AstraZeneca group of companies.