Hepatocellular carcinoma

is indicated for the treatment of hepatocellular carcinoma

Renal cell carcinoma

is indicated for the treatment of patients with advanced renal cell carcinoma who have failed prior interferon-alpha or interleukin-2-based therapy or are considered unsuitable for such therapy.

Differentiated thyroid carcinoma

Nexavar is indicated for the treatment of patients with progressive, locally advanced, or metastatic, differentiated (papillary/follicular/Hürthle cell) thyroid carcinoma, refractory to radioactive iodine.

Contraindications

Hypersensitivity to the active substance or to any of the excipients

There is no specific treatment for sorafenib overdose. The highest dose of sorafenib studied clinically is 800 mg twice daily. The adverse events observed at this dose were primarily diarrhea and dermatological events. In the event of suspected overdose sorafenib should be withheld and supportive care instituted where necessary.