LORNOXICAM 8 MG 20 TAB

Lornoxicam is a new nonsteroidal anti-inflammatory drug (NSAID) of the oxicam class with analgesic.  In addition, it has anti-inflammatory and antipyretic properties. Lornoxicam differs from other oxicam compounds. It has potent inhibition of prostaglandin biosynthesis. It’s a property that explains the particularly pronounced efficacy of the drug.

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LORNOXICAM 8 MG 20 TAB

Lornoxicam is a new nonsteroidal anti-inflammatory drug (NSAID) of the oxicam class with analgesic.  In addition, it has anti-inflammatory and antipyretic properties. Lornoxicam differs from other oxicam compounds. It has potent inhibition of prostaglandin biosynthesis. It’s a property that explains the particularly pronounced efficacy of the drug.

 

ACTIVE-INGREDIENT OF LORNOXICAM 

Lornoxicam

 

THERAPEUTIC INDICATIONS

For the treatment of acute mild to moderate pain, as well as pain and inflammation of the joints caused by certain types of rheumatic diseases.

 

MECHANISM OF ACTION

Lornoxicam is a non-steroidal anti-inflammatory drug (NSAID) that belongs to the oxicam class. As with other NSAIDS, lornoxicam is a potent inhibitor of the cyclooxygenase enzymes, which are responsible for catalyzing the formation of prostaglandins (act as messenger molecules in the process of inflammation) and thromboxane from arachidonic acid. Unlike some NSAIDS, lornoxicam’s inhibition of cyclooxygenase does not lead to an increase in leukotriene formation, meaning that arachidonic acid is not moved to the 5-lipoxygenase cascade, resulting in the minimization of the risk of adverse events.

 

PHARMACODYNAMICS

It is a non-steroidal anti-inflammatory drug (NSAID) that belongs to the oxicam class. As with other NSAIDS. It is a potent inhibitor of the cyclooxygenase enzymes, which are responsible for catalyzing the formation of prostaglandins (act as messenger molecules in the process of inflammation) and thromboxane from arachidonic acid. Unlike some NSAIDS, lornoxicam’s inhibition of cyclooxygenase does not lead to an increase in leukotriene formation, meaning that arachidonic acid is not moved to the 5-lipoxygenase cascade, resulting in the minimization of the risk of adverse events.

 

WHAT IS THE DOSE OF LORNOXICAM ?

Pain
8-16 mg lornoxicam daily divided into 2 or 3 doses. Maximum recommended daily dose is 16 mg.

Osteoarthritis and rheumatoid arthritis
Initial recommended dose is 12 mg lornoxicam daily divided into 2 or 3 doses. Maintenance dose
should not exceed 16 mg lornoxicam daily.

CONTRAINDICATIONS

  • Hypersensitivity to the active substance or to any of the excipients
  • Thrombocytopenia – Hypersensitivity (symptoms like asthma, rhinitis, angioedema or urticaria) to other NSAIDs including acetylsalicylic acid
  • Severe heart failure
  • Gastro-intestinal bleeding, cerebrovascular bleeding or other bleeding disorders
  • History of gastrointestinal bleeding or perforation, related to previous NSAIDs therapy
  • Active or history of recurrent peptic ulcer/haemorrhage (two or more distinct episodes of proven ulceration or bleeding)
  • Severe hepatic impairment – Severe renal impairment (Serum creatinine > 700 µmol/L) – The third trimester of pregnancy

 

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