Jardiance 25 mg 28 tab

Active Ingredient 

Empagliflozin

Therapeutic Use

Type 2 Diabetes Mellitus

Indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes

Also indicated to reduce the risk of cardiovascular death in adults with type 2 diabetes mellitus and cardiovascular disease.

496.50 EGP

Purchase this product now and earn 497 Points!

Jardiance 25 mg 28 tab

Active Ingredient 

Empagliflozin 

Therapeutic Use of Jardiance 25 mg 

Type 2 Diabetes Mellitus

Indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes

Also indicated to reduce the risk of cardiovascular death in adults with type 2 diabetes mellitus and cardiovascular disease.

Mechanism Of Action of Jardiance 25 mg

By inhibiting sodium-glucose cotransporter 2 (SGLT2) in the proximal renal tubules, empagliflozin reduces reabsorption of filtered glucose from the tubular lumen and lowers the renal threshold for glucose (RTG). SGLT2 is the main site of filtered glucose reabsorption; reduction of filtered glucose reabsorption and lowering of RTG result in increased urinary excretion of glucose, thereby reducing plasma glucose concentrations.

Distribution

Vd: 73.8 L

Metabolism

Primarily through glucuronidation by UGT2B7, UGT1A3, UGT1A8, and UGT1A9 to minor metabolites

Excretion

Urine (54.4%; 50% as unchanged drug); feces (41.2%; majority as unchanged drug)

Drug Interactions

Loop Diuretics: Empagliflozin may enhance the hypotensive effect of Loop Diuretics. Monitor therapy

Maitake: May enhance the hypoglycemic effect of Blood Glucose Lowering Agents. Monitor therapy

Monoamine Oxidase Inhibitors: May enhance the hypoglycemic effect of Blood Glucose Lowering Agents. Monitor therapy

Nitisinone: May increase the serum concentration of OAT1/3 Substrates. Monitor therapy

Pegvisomant: May enhance the hypoglycemic effect of Blood Glucose Lowering Agents. Monitor therapy

Pretomanid: May increase the serum concentration of OAT1/3 Substrates. Monitor therapy

Prothionamide: May enhance the hypoglycemic effect of Blood Glucose Lowering Agents. Monitor therapy

Adverse Effects

  • Urinary tract infection (7.6-9.3%)
  • Female genital mycotic infections (5.4-6.4%)
  • Upper respiratory tract infection (3.1-4%)
  • Increased urination (3.2-3.4%)
  • Dyslipidemia (2.9-3.9%)
  • Male genital mycotic infections (1.6-3.1%)
  • Arthralgia (2.3-2.4%)
  • Nausea (1.1-2.3%)
  • Polydipsia (1.5-1.7%)

Read More: 

Empagliflozin: Dosage, Mechanism/Onset of Action, Half-Life – Medicine.com

 

 

 

 

 

1 review for Jardiance 25 mg 28 tab

  1. Ahmed (verified owner)

    Ok

Add a review

Your email address will not be published.

Shopping Cart
Don`t copy text!
Scroll to Top