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CIPRODIAZOL  (Metronidazole and ciprofloxacin) are both types of antibiotics used to treat bacterial infections.

  • Metronidazole treats some parasitic infections.
  • These two active constituents are in different antibiotic drug classes.
  • Metronidazole is in the nitroimidazole antibiotic drug class, and ciprofloxacin is in the fluoroquinolone class of antibiotics.


Active Constituents

Metronidazole and ciprofloxacin


Common side effects of Ciprodiazole

  • Nausea
  • Vomiting
  • Abdominal Pain
  • Diarrhoea
  • Rash
  • Dry Mouth
  • Metallic taste
  • Headache
  • Loss of appetite
  • Weight Loss
  • Dizziness
  • Constipation
  • Nasal Congestion


How do they work?

  • Ciprofloxacin is a fluoroquinolone antibiotic used treats many types of bacterial infections.
  • It treats acute sinusitis, bone and joint infections, chronic bacterial prostatitis, infectious diarrhea, as empirical therapy in febrile neutropenic patients, intra-abdominal infections, lower respiratory tract infections.
  • It also treats lung infections, chronic bronchitis, urinary tract infections, urethral and cervical gonococcal infections, anthrax infection, intra-abdominal infections and typhoid fever.
  • Metronidazole is an antibiotic effective against anaerobic bacteria and certain parasites.
  • It treats anaerobic bacterial infections, sexually transmitted diseases, bacterial vaginosis, colorectal surgical infection, abscesses in the liver/pelvis/abdomen.
  • Metronidazole also may be used in combination with other drugs to treat H. pylori infection that causes stomach or intestinal ulcers.


What are the therapeutic indications of Ciprodiazole?

  • Skin infections
  • Lung or airway Infections, for example, TB (tuberculosis), pneumonic and septicemic plague due to Yersinia pestis (Y. pestis), lower respiratory tract infections, and chronic bronchitis)
  • Bone infections
  • Joint infections
  • Urinary tract infections (UTI) caused by certain bacteria such as E. coli.
  • Infectious diarrhoeas caused by E. coliCampylobacter jejuni, and Shigella bacteria.
  • Anthrax patients with fever and low white blood cell counts, and intra-abdominal infections.
  • Typhoid fever
  • Cervical and urethral gonorrhoea due to Neisseria gonorrhoeae
  • Chronic bacterial prostatitis
  • Acute uncomplicated cystitis
  • Metronidazole treats parasitic infections including Giardia infections of the small intestine, amebic liver abscess, and amebic dysentery (infection of the colon causing bloody diarrhoea), bacterial vaginosis, trichomonas vaginal infections, and carriers of trichomonas (both sexual partners) who do not have symptoms of infection.
  • It is also used alone or in combination with other antibiotics in treating abscesses in the liver, pelvis, abdomen, and brain caused by susceptible anaerobic bacteria.
  • Ciprodiazole treats infection of the colon caused by a bacterium called C. difficile. Many commonly-used antibiotics can alter the type of bacteria that inhabit the colon. C. difficile is an anaerobic bacterium that can infect the colon when the normal types of bacteria in the colon are inhibited by common antibiotics. This leads to inflammation of the colon (pseudomembranous colitis) with severe diarrhoea and abdominal pain.)
  • It is also used in combination with other drugs to treat Helicobacter pylori (H. pylori) which causes stomach or intestinal ulcers.


What is the dosage of Ciprodiazole?

Ciprofloxacin dosage

  • For most infections, the recommended oral dose for adults is 250-750 mg (immediate-release tablets) every 12 hours or 500-1000 mg (extended-release tablets) every 24 hours.

Metronidazole dosage

  • Take Metronidazole orally with or without food.
  • In the hospital, you can take metronidazole intravenously to treat serious infections.
  • The liver is primarily responsible for eliminating metronidazole from the body, and clinical pharmacists may need to reduce the doses in patients with liver disease and abnormal liver function.

Take 1 tablet twice daily every 12 hours. 


What are the drug interactions that occur with Ciprodiazole?

  • you shouldn’t take ciprofloxacin with theophylline can lead to elevated, toxic blood levels of theophylline.
  • Toxic levels of theophylline can lead to seizures and disturbances in heart rhythm.
  • Ciprofloxacin increases the effect of tizanidine that treats muscle spasticity.
  • Iron salts (for example, ferrous sulfate) may reduce the absorption of ciprofloxacin because of the formation of a ciprofloxacin-iron complex that is not absorbable. Antacids also may reduce the absorption of ciprofloxacin.
  • If you are receiving iron salts or antacids and ciprofloxacin, you should receive ciprofloxacin two hours before or six hours after the iron salt or antacid.
  • Ciprofloxacin may increase the blood-thinning effect of warfarin. You should monitor Anticoagulant activity after starting or stopping ciprofloxacin.
  • Administration of ciprofloxacin with diabetic medications (for example glyburide may lead to severe low blood glucose.
  • Ciprofloxacin may increase blood concentrations of sildenafil (Viagra) that treats erectile dysfunction. You shouldn’t take this combination.
  • Patients taking Cipro can increase the sensitivity of the skin to direct sunlight (photosensitivity) and should avoid exposure to sunlight or use sunblock.
  • Fluoroquinolones worsen low blood glucose levels when combined with sulfonylureas, for example, glyburide.
  • You shouldn’t drink alcohol because metronidazole and alcohol together can cause severe nausea, vomiting, cramps, flushing, and headache.
  • Metronidazole increases the blood levels of carbamazepine, lithium (Eskalith, Lithobid) and cyclosporine through unknown mechanisms. Serious reactions may occur with this combination.


Special Population:
Pregnancy and Breastfeeding
  • Doctors suggest that should not use Ciprodiazole if you are pregnant or breastfeeding because they do not know if it is safe.
  • Preganant women shouldn’t take Metronidazole in their early pregnancy because of potential adverse effects on the fetus. Breast milk will contain metronidazole. Females who are nursing, because of potential adverse effects on the newborn, should not use metronidazole.





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1 review for CIPRODIAZOLE 500MG 20 TAB

  1. yara

    مضاد حيوي كويس

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