CETAL TAB

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Description

CETAL TAB

Cetal (Paracetamol) is a pain reliever and a fever reducer. The exact mechanism of action of is not known.

Paracetamol is used to treat many conditions such as headache, muscle aches, arthritis, backache, toothaches, colds, and fevers. It relieves pain in mild arthritis but has no effect on the underlying inflammation and swelling of the joint.

Paracetamol may also be used for other purposes not listed in this medication guide.

 

Active Ingredient of Cetal

Paracetamol

 

 

What is Paracetamol?

Paracetamol is a pain reliever and a fever reducer. It acts as COX-III inhibitor. (Cyclooxygenase enzyme)

Paracetamol is used to treat many conditions such as headache, muscle aches, arthritis, backache, toothaches, colds, and fevers. It relieves pain in mild arthritis but has no effect on the underlying inflammation and swelling of the joint.

Paracetamol may also be used for other purposes not listed in this medication guide.

 

CETAL (Paracetamol) side effects

  • low fever with nausea, stomach pain, and loss of appetite;
  • dark urine, clay-colored stools; or
  • Jaundice (yellowing of the skin or eyes).

Paracetamol may cause: 

  • Bloody or black, tarry stools
  • bloody or cloudy urine
  • fever with or without chills (not present before treatment and not caused by the condition being treated)
  • pain in the lower back and/or side (severe and/or sharp)
  • pinpoint red spots on the skin
  • skin rash or itching
  • sore throat (not present before treatment and not caused by the condition being treated)
  • sores, ulcers, or white spots on the lips or in the mouth
  • sudden decrease in the amount of urine
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • yellow eyes or skin

 

What are the symptoms of overdose of CETAL (paracetamol) ?

  • Increased sweating
  • loss of appetite
  • Nausea or vomiting
  • stomach cramps or pain
  • swelling, pain, or tenderness in the upper abdomen or stomach area

 

Dosing information

Usual Adult Paracetamol Dose for Fever:

General Dosing Guidelines: 325 to 650 mg every 4 to 6 hours or 1000 mg every 6 to 8 hours orally or rectally.

Paracetamol 500mg tablets: Two 500 mg tablets orally every 4 to 6 hours

 

Usual Adult Paracetamol Dose for Pain:

General Dosing Guidelines: 325 to 650 mg every 4 to 6 hours or 1000 mg every 6 to 8 hours orally or rectally.

Paracetamol 500mg tablets: Two 500 mg tablets orally every 4 to 6 hours

 

Usual Pediatric Dose for Fever:

Oral or Rectal:

<=1 month: 10 to 15 mg/kg/dose every 6 to 8 hours as needed.

>1 month to 12 years: 10 to 15 mg/kg/dose every 4 to 6 hours as needed (Maximum: 5 doses in 24 hours)

Fever: 4 months to 9 years: Initial Dose: 30 mg/kg (Reported by one study (n=121) to be more effective in reducing fever than a 15 mg/kg maintenance dose with no difference regarding clinical tolerance.)

>=12 years: 325 to 650 mg every 4 to 6 hours or 1000 mg every 6 to 8 hours.

 

Usual Pediatric Dose for Pain:

Oral or Rectal:

<=1 month: 10 to 15 mg/kg/dose every 6 to 8 hours as needed.

>1 month to 12 years: 10 to 15 mg/kg/dose every 4 to 6 hours as needed (Maximum: 5 doses in 24 hours)

Fever: 4 months to 9 years: Initial Dose: 30 mg/kg (Reported by one study (n=121) to be more effective in reducing fever than a 15 mg/kg maintenance dose with no difference regarding clinical tolerance.)

>=12 years: 325 to 650 mg every 4 to 6 hours or 1000 mg every 6 to 8 hours

 

Paracetamol (acetaminophen) disease interactions

There are 3 diseases with Paracetamol (acetaminophen) which include:

  • Alcoholism
  • Liver disease
  • PKU

 

Special Population

Paracetamol Pregnancy Warnings

According to published animal studies, acetaminophen may cause reduced fertility in both males and females described as decreased testicular weights, reduced spermatogenesis, reduced fertility; and reduced implantation sites, respectively.

Benefit should outweigh risk

AU TGA pregnancy category: A

Risk Summary: A clear association of drug use and birth defects, miscarriage, or adverse maternal or fetal outcomes has not been shown with human use; animal studies have demonstrated adverse events at clinically relevant doses.

 

Paracetamol Breastfeeding Warnings

Caution is recommended.

Excreted into human milk: Yes

 

Acetaminophen Pharmacokinetics
Absorption and Bioavailability

Well absorbed following oral administration, with peak plasma concentration attained within 10–60 minutes (immediate-release preparations) or 60–120 minutes (extended-release preparations).

Poor or variable absorption following rectal administration; considerable variation in peak plasma concentrations attained; time to reach peak plasma concentration is substantially longer than after oral administration.

Pharmacokinetics of IV acetaminophen are dose proportional at doses of 0.5–1 g.

Systemic exposure is similar following IV or oral administration, but peak plasma concentration at end of 15-minute IV infusion is up to 70% higher than peak concentration following oral administration of same dose.

Following single-dose IV administration in pediatric patients (15-mg/kg dose) or adults (1-g dose), systemic exposure in children and adolescents is similar to that in adults, but exposure is higher in neonates and infants. Simulations suggest that dose reductions of 33% in infants 1 month to <2 years of age and 50% in neonates up to 28 days of age, with a minimum dosing interval of 6 hours, would result in systemic exposures similar to those observed in children ≥2 years of age.

 

Coronavirus (Covid-19) and paracetamol

Most people with coronavirus (COVID-19) feel better within a few weeks. You may be able to look after yourself at home while you recover. If you have a high temperature it can help to:

  • Get lots of rest
  • Drink plenty of fluids
  • Take paracetamol or ibuprofen if you feel uncomfortable

 

What are the alternatives of Cetal ?

Paracetamol tab

Doliperan tab 

Panadol advance tab

Adol tab

Abimol tab

Paramol tab 

 

Read More

 

 

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