CAPOTEN 50MG TAB
Captopril, cardiovascular agents
ACTIVE-INGREDIENT OF CAPOTEN 50MG TAB
INDICATION OF CAPOTEN 50MG TAB
- Captopril treats high blood pressure (hypertension). Lowering high blood pressure helps prevent strokes,
- Prevents heart attack, and kidney problems.
- It is also used to treat heart failure, protect the kidneys from harm due to diabetes and to improve survival after a heart attack.
- Captopril is an ACE inhibitor and works by relaxing blood vessels so that blood can flow more easily.
- Diabetic Nephropathy
- Left Ventricular Dysfunction After Myocardial Infarction
Side Effects Of Capoten
- little or no urination,
- urinating more than usual,
- shortness of breath,
- rapid weight gain,
- chest pain or pressure,
- pounding heartbeats,
- fluttering in your chest,
- slow or unusual heart rate,
- loss of movement,
- sudden weakness,
- ill feeling,
- Sore throat,
- painful mouth sores,
- pain when swallowing,
- skin sores, and
- cold or flu symptoms
The usual dose range is 25 to 150 mg b.i.d. or t.i.d. You shouldn’t exceed a maximum daily dose of 450 mg CAPOTEN.
Mechanism Of Action
Its beneficial effects in hypertension and heart failure appear to result primarily from suppression of the renin-angiotensin aldosterone system. However, there is no consistent correlation between renin levels and response to the drug. Renin, an enzyme synthesized by the kidneys, is released into the circulation where it acts on a plasma globulin substrate to produce angiotensin I, a relatively inactive decapeptide. Angiotensin I is then converted by angiotensin converting enzyme (ACE) to angiotensin II, a potent endogenous vasoconstrictor substance. Angiotensin II also stimulates aldosterone secretion from the adrenal cortex, thereby contributing to sodium and fluid retention.
Clinical efficacy of sublingual captopril in the treatment of hypertensive urgency
This study aimed to evaluate the response rate, clinical efficacy and onset of action of sublingual captopril in patients diagnosed with hypertensive urgency.
You can use sublingual captopril and it’s effective, easily applicable and safe treatment in the management of hypertensive urgency for 120 minutes for those who do not receive multidrug antihypertensive regimens.
Sublingual vs. Oral Captopril in Hypertensive Crisis
Oral and sublingual captopril is compared its effectiveness over BP decrease in patients admitted to our Emergency Department with hypertensive urgency.
Sublingual captopril decreases BP more efficiently in the first 30 min than oral captopril but this difference equalized at 60 min between both dosage forms.