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BRUFEN 200MG 30TAB; ibuprofen, anti inflammatory agents .


One tablet contains 200 mg Ibuprofen.


Brufen is indicated for analgesic and anti-inflammatory effects in the treatment of rheumatoid arthritis (including juvenile rheumatoid arthritis or Still’s disease), ankylosing spondylitis, osteoarthritis and other non-rehumatoid (seronegative) arthropathies. In the treatment of non-articular rheumatic conditions, Brufen is indicated in periarticular conditions such as frozen shoulder (capsulitis), bursitis, tendonitis, tenosynovitis and low back pain; Brufen can also be used in soft tissue injuries such as sprains and strains. Brufen is also indicated for its analgesic effect in the relief of mild to moderate pain such as dysmenorrhoea, dental and post-operative pain and for symptomatic relief of headache, including migraine headache.


Follow all directions given to you by your pharmacist or doctor carefully . They may differ from the information contained in this leaflet

Ask your pharmacist or doctor for help if you do not understand the instructions on the box .

The recommended dose is : –

Undesirable effects may be minimized by using the lowest effective dose for the shortest duration necessary to control symptoms. The recommended dose is 1200 to 1800 mg/day in divided doses. Some patients can be maintained on 600 to 1200 mg/day. In severe and acute cases, it could be adventageous to increase the dosage until the acute phase is over. Daily dose should not exceed 2400 mg in divided doses. Adults and children over 12 years of age: The recommended dosage of Burfen is 1200-1800 mg daily in divided doses. Some patients can be maintained on 600-1200 mg daily . In severe or acute conditions, it can be adventageous to increase the dosage until the acute phase is brought under control, provided that the total daily dose does not exceed 2400 mg in divided doses. Children: The daily dosage of Burfen is 20 mg/kg of body weight in divided doses. For young children , more suitable formulations are available . In juvenile Rheumatoid Arthritis, up to 40 mg/kg of body weight daily in divided doses may be taken. Not recommended for children weighing less than 7 kg. Elderly: The elderly are at increased risk of serious consequences of adverse reactions. If an NSAID is considered necessary, the lowest effective dose should be used and for the shortest possible duration. The patient should be monitored regularly for GI bleeding during NSAID therapy. If renal or hepatic function is impaired, dosage should be assessed individually. For oral administration. It is recommended that patients with sensitive stomachs take Burfen with food . If taken shortly after eating, the onset of action of Burfen may be delayed. To be taken preferably with or after food, with plenty of fluid. Burfen tablets should be swallowed whole and not chewed, broken , crushed or suked on to avoid oral discomfort and throate irritation. Ensure the Burfen Granules are dissolved in plenty of water. A transient sensation of burning in the mouth or throat may occur with Brufen Granules.


Toxicity : Signs and symptoms of toxicity have generally not been observed at doses below 100 mg/kg in children or adults. However, supportive care may be needed in some cases. Children have been observed to manifest signs and symptoms of toxicity after ingestion of 400 mg/kg or greater. Symptoms: Most patients who have ingested significant amounts of ibuprofen will manifest symptoms within 4 to 6 hours. The most frequently reported symptoms of overdose include nausea, vomiting, abdominal pain, lethargy and drowsiness. Central nervous system (CNS) effects include headache, tinnitus, dizziness, convulsion, and loss of consciousness. Nystagmus, metabolic acidosis, hypothermia, renal effects, gastrointestinal bleeding, coma, aponea, diarrhoea and depression of the CNS and respiratory system have also been rarely reported. Disorientation,excitation, fainting anmd cardiovascular toxicity, including hypotension, bradycardia and tachycardia have been reported. In cases of significant overdose, renal failure and liver damage are possible. Large overdoses are generally well tolerated when no other drugs are being taken. Therapeutic measures: Patients should be treated symptomatically as required. Within one hour of ingestion of a potentially toxic amount, activated charcoal should be considered. Alternatively, in adults, gastric lavage should be considered within one hour of ingestion of a potentially life-threatining overdose. Good urine output should be ensured. Renal and liver function should be closely monitored. Patients should be observed for at least four hours after ingestion of potentially toxic amounts. Frequent or prolongedconvulsions should be treated with intravenous diazepam. Other measures may be indicated by the patient’s clinical condition.


Burfen is containdicated in patients with hypersensitivity to the active substance or to any of the excipents. Brufen should not be used in patients who have previously shown hypersensitivity reactions (e.g. asthma,urticaria, angioedema or rhinitis) after taking ibuprofen,aspirin or other NSAIDs. Burfen is also contraindicated in patients with a history of gastrointestinal bleeding or perforation, related to previous NSAID therapy. Burfen should not be used in patients with active, or historyof, recurrent peptic ulcer or gastrointestinal haemorrhage ( two or more distinct episodes of proven ulceration or bleeding ). Burfen should not be given to patients with conditions involving an increased tendency to bleeding. Burfen is contraindicated in patients with severe heart failure ( NYHA Class IV ), hepatic failure and renal failure. Cardiovascular risk: NSAIDs may cause an increased risk of serious cardiovascular thrombotic events, myocardial infraction, and stroke, which can be fatal. This risk may increase with duration of use. Patients with cardiovascular disease of risk factors for cardiovascular disease may be at greater risk. NSAIDs are contraindicated for the treatment of peri-operative pain in the setting coronary artery bypass graft (CABG) surgery. Gastrointestinal risk: NSAIDs cause an increased risk of serious gastrointestinal adverse events including inflammation, bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events, can occur at any time during use and without warning symptoms. Elderly patients are at risk for serious gastrointestinal events. Brufen is contraindicated during last trimester of pregnancy.


Store at temperature not exceeding 30 °C, in a dry place and away from light.
Carton box contains 3 (Al/ transparent PVC) strips, each of 10 sugar coated tablets and inner leaflet.
Kahira pharma & Chem , Ind , Co.under licence of Abbott laboratories USA and its branches.

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