APIDRA SOLOSTAR PEN

350.00 EGP

APIDRA SOLOSTAR PEN

Insulin glulisine, blood glucose regulators

ACTIVE INGREDIENT

Insulin Glulisine

INDICATION OF APIDRA SOLOSTAR

  • Diabetes Mellitus Type I or II
  • Indicated to improve glycemic control in adults and children with diabetes mellitus

 

DOSAGE OF APIDRA 

  • Injectable solution (as 10 mL vial and 3 mL cartridge)

100 units/mL

  • Prefilled 3 mL pen (Solostar)

100 units/mL

  • Apidra is indicated to improve glycemic control in adults and children with diabetes mellitus
  • Dosage of human insulin, which is always expressed in USP units, must be based on the results of blood and urine glucose tests and must be carefully individualized to optimal effect
  • <4 years: Safety and efficacy not established
  • 4-17 years: May require 0.8-1.2 units/kg/day SC during growth spurts; otherwise use adult dosing (0.5-1 unit/kg/day)

Mechanism of Action Of APIDRA

Protein hormone

Insulins lower blood glucose by stimulating peripheral glucose uptake by skeletal muscle and fat, and by inhibiting hepatic glucose production

Absorption

Bioavailability: 70% following SC

Onset: 20 min (SC abdominal or deltoid injection); 30 min (SC femoral injection)

Peak Plasma Time: 1 hr

Peak Plasma Concentration: 83 microUnits/mL

Duration of action: 5 hr

Distribution

Protein Bound: 5% (not bound to serum binding-protein, but present as a monomer in plasma)

Vd: 13 L

Metabolism

Liver >50%; kidney 30%; adipose tissue/muscle 20%

Elimination

Half-Life: 13 minutes (IV); 42 min (SC)

 

Novo Rapid vs Apidra vs Humalog

Apidra (Insulin glulisine), Novo Rapid (Insulin Aspart) and Humalog (Insulin Lispro) are rapid acting analog insulins produced by recombinant DNA technology. They are chemically identical to human insulin except that: in Novo Rapid the amino acid Proline has been substituted for aspartic acid at position B28 of the insulin molecule. In Humalog the location of the 2 amino acids lysine and proline have been changed.

In conclusion, these structural changes give Novo Rapid and Humalog a much more rapid onset of action and a shorter duration of action than regular insulin.

Regular Insulin has an onset of action about 1 hour after injection and the effect peaks in 4 hours and lasts 6 hours.

STORAGE OF APIDRA SOLOSTAR

Keep unused bottles, cartridges, and pens of insulin in the refrigerator, Keep insulin cartridges and pens that you’re currently using at room temperature
PACK OF APIDRA SOLOSTAR

 

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