ANAPRAMINE SR 10 TAB; clomipramine, antidepressants .
ACTIVE-INGREDIENT OF ANAPRAMINE SR 10 TAB
Each SR film tablet contains: Clomipramine hydrochloride 75 mg.
INDICATION OF ANAPRAMINE SR 10 TAB
Clomipramine hydrochloride is used to treat: Depressive states of varying aetiology and symptomatology, e.g.: Endogenous, reactive, neurotic, organic, masked, and involutional forms of depression. Depression associated with schizophrenia and personality disorders. Depressive syndroms due to pre-senility or senility, to chronic painful conditions, and to chronic somatic diseases. Depressive mood disorders of a reactive, neurotic, or psychopathic nature. Obsessive – compulsive syndromes. Phobias and panic attacks. Cataplexy accomanying narcolepsy. Chronic painful conditions. Nocturnal enuresis (only in patients over the age of 5 and if organic causes have been excluded).
DOSAGE OF ANAPRAMINE SR 10 TAB
Follow all directions given to you by your pharmacist or doctor carefully . They may differ from the information contained in this leaflet
Ask your pharmacist or doctor for help if you do not understand the instructions on the box .
The recommended dose is : –
The sustained release tablets should be swallowed as a whole, don’t divide or chew. Depression, Obsessive – compulsive syndromes, and Phobias: Start treatment with 1 sustained release tablet of 75 mg once daily (preferably in the evining). Raise the daily dosage stepwise, to 2 sustained release tablets of 75 mg during the first week of treatment. In severe cases this dosage can be increased up to maximum of 250 mg daily . Once there is a distinct improvement, adjust the daily dosage to a maintenance level of about 50-100 mg or 1 modified release tablet of 75 mg. Panic attacks, agoraphobia: Start with 1 tablet of 10 mg daily, possibly in combination with a benzodiazepine, Depending on how the medication is tolerated, raise the dosage until the desired response is obtained, while gradually withdrawing the benzodiazepine. The daily dosage required varies greatly from patient to patient and lies between 25 and 100 mg . If necessary it can be increased to 150 mg. It is advisable for treatment not to be discontinued for at least 6 months and for the maintenance dose to be redduced slowly during this time. Cataplexy accomanying narcolepsy: Daily dose of 25-75 mg. Chronic painful conditions: The dosage must be individualized 10-150 mg daily, while taking account of cocomitant analgesic medication ( and of the possibility of reducing use of analgesics ). Nocturnal enuresis: Initial daily dose in children aged 5-8 years: 20-30 mg. Initial daily dose in children aged 9-12 years: 25-50 mg. Initial daily dose in older children : 25-75 mg. The coated tablets should normally be given in a single dose after the evining meal, but children who wet their beds early in the night should be given part of the dose earlier (at 4 p.m.). Once the desired response has been achieved, treatment should be continued (for 1-3 months) and the dose gradually reduced.
OVER-DOSAGE OF ANAPRAMINE SR 10 TAB
CONTRA-INDICATION OF ANAPRAMINE SR 10 TAB
Anapramine is contraindicated in the following cases: Patients who have known hypersensitivity to the drug or have known hypersensitivity to tricyclic antidepressents belonging to the dibenzazepine group. Recent myocardial infraction. Patients who treated with MAO inhibitors or within 14 days before or after treatment with a MAO inhibitors.
STORAGE OF ANAPRAMINE SR 10 TAB
Store in a dry place at a temperature not exceeding 30 °C.
PACK OF ANAPRAMINE SR 10 TAB
A box containing a blister of 10 tablets.
ANAPRAMINE SR 10 TAB MANUFACTURED BY
SIGMA Pharmaceutical Industries . Egypt . S.A.E.