ADOLOR 15MG AMP; ketorolac, anti inflammatory agents .
ACTIVE-INGREDIENT OF ADOLOR 15MG AMP
adolor ampoules contain ketorolac tromethamine 15 mg/1 ml .
INDICATION OF ADOLOR 15MG AMP
adolor ampoules is indicated for the the short-term management of moderate to severe acute post-operative pain . Treatment should only be initiated in hospitals . The maximum duration of treatment is two days .
DOSAGE OF ADOLOR 15MG AMP
Follow all directions given to you by your pharmacist or doctor carefully . They may differ from the information contained in this leaflet
Ask your pharmacist or doctor for help if you do not understand the instructions on the box .
The recommended dose is : –
adolor ampoules is for administeration by intrmuscular or intravenous injection . Intravenous doses should be given over no less than 15 seconds . Adolor ampoules : should not be used for eposural or spinal administration . The time to onset of analgesic effect following both iv and im administration is similar is approximately 30 minutes , with maximum analgesia occurring within one to two hours . the median duration of analgesia is generally four to six hours . dosage should be adjusted according to the severity of the pain and the patient response . the administration of continuous multiple daily doses of ketorolac intramuscularty or intravenously should not should not exceed two days because adverse events may increase with prolonged usage . there has been limited experience with dosing for longer since the vast majority of patients have transferred to oral medication or no longer require analgesic therapy after this time . undesirable effects may be minimized by using the lowest duration necessary to control symptoms . adults : the recommended initial dose of adolor is 15 mg , followed by a dose up to 30 mg every four to six hours as required . in the initial post-operative period , adolor ampoules may be given as often as every , a total daily dose of 90 mg for non -elderly and 60 mg for the elderly , renally -impaired patients and patients less than 50 kg should be exceeded . the maximum duration of treatment should not exceed two days . reduce dosage in patients under 50 kg . opioid analgesics (e.g. morphine , pethidine ) may be used concomitantly , and may be required for optimal analgesic effect in the elderly post -operative period when pain is most severe . ketorolac does not exacerbate opioid-related respiratory depression or sedation . when used in association with adolor im/iv , the daily dose of opioid is usually less than that normally required . however , opioid side-effects should still be considered , espicially in day -case surgery . for patients receving parenteral adolor , and who are converted to ketorolactromethamine oral tablets , the total combined daily dose should not exceed 90 mg ( 60 mg for the elderly , renally – impaired patients less than 50 kg ) and the oral component should not exceed 40 mg on the day the change of formulation is made . patients should be converted to oral treatment as soon as possible. elderly : the elderly are at increased risk of the serious consequences of adverse reactions . if an NSAID is considered necessary , the lowest effective dose should be used and the shortest possible duration . the patients should be monitored regularly for GI bleeding during NSAID therapy . a total daily dose of 60 mg should not be exceeded . children : safety and efficacy in children have not been established . therefore , adolor is not recommended for use in children 16 years of age . renal impairment : contra-indicated in moderate to severe renal impairment , reduce dosage in lesser impairment ( not exceeding 60 mg/day iv or im ) .
OVER-DOSAGE OF ADOLOR 15MG AMP
symptoms and sings : single ketorolac have been variously associated with abdominal pain , nausea , vomiting , hyperventilation , peptic ulcers and/or erosive gastritis and renal dysfunction which have resolved after discontinuation of dosing
CONTRA-INDICATION OF ADOLOR 15MG AMP
pregnancy , nursing mothers & pediateric use . Do not administer injections preserved with benzyl alcohol to neonates , infants , pregnant women or nursing mothers . Benzyl alcohol has been associated with serious events & death , particularly in pediatric patients . injections preservative free should be used in these populations . ketorolac is xontraindicated in patients with previously demonstrated hypersensitivity in whom aspirin or other prostaglandin synthesis inhibitors induce allergic reactions ( severe anaphylactic -like reactions have been observed ( in such patients) . such reactions have included have included asthma , rhinitis , angioedema , or urticaria . ketorolac is also contraindicated – those with with a history of asthma – children under 16 years of age . ketorolac is contraindicated in patients with history of gastrointestinal bleeding of perfortion , related to previous NSAIDs therapy , active or history of recurrent peptic ulcer / haemorrhage ( two or more distinct episodes of proven ulceration or bleeding ) as with other NSAIDS , ketorolac is contraindicated in patients with severe heart failure , hepatic failure and renal failure . ketorolac is contraindicated in patients with moderate or severe renal impairment (serum creatinine > 160 µmol /l ) or in patients at risk for renal failure due to volume depletion or dehydration . ketorolac is contraindicated in pregnancy , labour , delivery or lactation . ketorolac is contraindicated as prophylactic anagesia before surgery due to inhibition of aggregation and is contraindicated intra-operatively because of the increased risk of bleeding .
STORAGE OF ADOLOR 15MG AMP
store at temperature not exceeding 30 C , away from light . Keep of the reach of children .
PACK OF ADOLOR 15MG AMP
carton box containing 3 brown glass ampoules , 1 ml each (15 mg/1 ml) .
ADOLOR 15MG AMP MANUFACTURED BY
PHARCO B International for Pharco Pharmaceuticals .