opzelura 1.5 for treatment of vitiligo

opzelura for treatment of vitiligo


The use of OPZELURA along with therapeutic biologics, other JAK inhibitors, or strong immunosuppressants such as azathioprine or cyclosporine is not recommended.

It is not known if OPZELURA is safe and effective in children less than 12 years of age with atopic dermatitis or nonsegmental vitiligo




OPZELURA is a prescription medicine used on the skin (topical) for:

  • short-term and non-continuous chronic treatment of mild to moderate eczema (atopic dermatitis) in non-immunocompromised adults and children 12 years of age and older whose disease is not well controlled with topical prescription therapies or when those therapies are not recommended
  • the treatment of a type of vitiligo called nonsegmental vitiligo in adults and children 12 years of age and older

treatment of vitiligo


OPZELURA may cause serious side effects, including:

Serious Infections: 

OPZELURA contains ruxolitinib. Ruxolitinib belongs to a class of medicines called Janus kinase (JAK) inhibitors. JAK inhibitors are medicines that affect your immune system. JAK inhibitors can lower the ability of your immune system to fight infections. Some people have had serious infections while taking JAK inhibitors by mouth, including tuberculosis (TB), and infections caused by bacteria, fungi, or viruses that can spread throughout the body. Some people have been hospitalized or died from these infections. Some people have had serious infections of their lungs while taking OPZELURA. Your healthcare provider should watch you closely for signs and symptoms of TB during treatment with OPZELURA.

OPZELURA should not be used in people with an active, serious infection, including localized infections. You should not start using OPZELURA if you have any kind of infection unless your healthcare provider tells you it is okay. You may be at a higher risk of developing shingles (herpes zoster) while using OPZELURA.

Increased risk of death due to any reason (all causes): 

Increased risk of death has happened in people 50 years of age and older who have at least 1 heart disease (cardiovascular) risk factor and are taking a medicine in the class of medicines called JAK inhibitors by mouth.

Cancer and immune system problems: 

OPZELURA may increase your risk of certain cancers by changing the way your immune system works. Lymphoma and other cancers have happened in people taking a medicine in the class of medicines called JAK inhibitors by mouth. People taking JAK inhibitors by mouth have a higher risk of certain cancers including lymphoma and lung cancer, especially if they are current or past smokers. Some people have had skin cancers while using OPZELURA. Your healthcare provider will regularly check your skin during your treatment with OPZELURA. Limit the amount of time you spend in the sunlight. Wear protective clothing when you are in the sun and use broad-spectrum sunscreen.

Increased risk of major cardiovascular events: 

Increased risk of major cardiovascular events such as heart attack, stroke, or death has happened in people 50 years of age and older who have at least 1 heart disease (cardiovascular) risk factor and taking a medicine in the class of medicines called JAK inhibitors by mouth, especially in current or past smokers.

Blood clots: 

Blood clots in the veins of your legs (deep vein thrombosis, DVT) or lungs (pulmonary embolism, PE) can happen in some people taking OPZELURA. This may be life-threatening. Blood clots in the vein of the legs (deep vein thrombosis, DVT) and lungs (pulmonary embolism, PE) have happened more often in people who are 50 years of age and older and with at least 1 heart disease (cardiovascular) risk factor taking a medicine in the class of medicines called JAK inhibitors by mouth.

Low blood cell counts: 

OPZELURA may cause low platelet counts (thrombocytopenia), low red blood cell counts (anemia), and low white blood cell counts (neutropenia). If needed, your healthcare provider will do a blood test to check your blood cell counts during your treatment with OPZELURA and may stop your treatment if signs or symptoms of low blood cell counts happen.

Cholesterol increases: 

Cholesterol increase has happened in people when ruxolitinib is taken by mouth. Tell your healthcare provider if you have high cholesterol or triglycerides.


How to use 

dose opzelura

  • The cream is to be used on the skin only, do not use it on the eyes, lips, or sensitive areas.
  • The cream is applied twice daily, with a maximum of 60 grams per week or 100 grams per two weeks, depending on the condition and area to be treated.
  • If the cream is used to treat eczema, stop using the cream as soon as symptoms disappear.
  • In the case of vitiligo treatment, the use of the cream should not exceed 24 weeks, especially if the symptoms have not improved.
  • Wash your hands well after you finish applying the cream unless the hands are from the affected parts and the cream was intentionally applied to them.

opzelura Dosages

The doses application vary, depending on the condition to be treated, to:

opzelura dose for eczema

Apply twice daily, in a thin layer of cream to a maximum of 20% of the body area at a time.

opzelura dose for vitiligo

Use the cream twice daily, to a maximum of 10% of the body area at a time.

Important Safety Information


 is for use on the skin only. Do not use OPZELURA in your eyes, mouth, or vagina.

Drugs that interact with opzelura

A number of drug interactions have been documented between the cream and the following treatments; It has been proven that combining them increases the side effects of the cream:

Antibiotics, such as: clarithromycin C.
Antifungals, such as: itraconazole and ketoconazole.
Treatment of HIV viruses, such as: atazanavir and retinavir.
Mifepristone (Mifepristone).


Other products for the treatment of vitiligo





Alternative medicines to opzelura

No other cream has the same effect or the same effect as contains an active substance similar to Ruxolitinib.



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